Mesenchymal Stem Cell Therapy Applications

Mesenchymal stem stromal cells mscs are multipotent cells with the ability to differentiate into several cell types thus serving as a cell reservoir for regenerative medicine.

Mesenchymal stem cell therapy applications.

There are insufficient data to assess use of mscs for the treatment of covid 19. Mesenchymal stem stromal cells are one of the most commonly studied stem cell populations and the most commonly used cell based therapy for neurodegenerative cardiovascular and other diseases in clinical trials because of their regenerative effects. Regenerative therapy is considered an emerging field of medicine focusing on repair replacement or regeneration of cells and tissues. Mesenchymal stem cell therapy is considered investigational for all orthopedic applications including use in repair or regeneration of musculoskeletal tissue.

This coverage policy addresses stem cell therapy for orthopaedic applications in particular mesenchymal stem cells mscs. Mscs are investigational products that have been studied extensively for broad clinical applications in regenerative medicine1 and for their immunomodulatory properties 2no mscs are approved by the food and drug administration fda for the treatment of covid 19. Mscs have been proposed as a type of regenerative therapy. Isolation characterization and potential applications of bovine mesenchymal stem cells.

Mesenchymal stem cells mscs bear a variety of properties such as the ability to differentiate into various cell lineages to secrete soluble factors crucial for cell survival and proliferation to migrate to the exact site of injury and to modulate the immune response. Adult mesenchymal stem cells are being used by researchers in the fields of regenerative medicine and tissue engineering to artificially reconstruct human tissue which has been previously damaged. To help discover the therapeutic uses of these stem cells they are grown in laboratories or by using medication to stimulate new cell growth within. Much of the current interest in therapeutic application of mscs to various disease settings can be linked to their immunosuppressive and anti inflammatory properties.

Allograft bone products containing viable stem cells including but not limited to demineralized bone matrix with stem cells are considered investigational for all orthopedic applications. Among all kinds of stem cells mesenchymal stem cells mscs have been shown to be an interesting therapeutic option due to their immunomodulatory properties and their potential for in vitro differentiation into insulin secreting cells. Mesenchymal stem cells have the capacity to become any type of fully developed cell which can contribute to replacing muscle tissues or internal organs. Mesenchymal stem cell therapy is considered experimental investigational for all orthopedic applications including use in repair or regeneration of musculoskeletal tissue.