Mesenchymal Stem Cells Knee Osteoarthritis

Osteoarthritis is a degenerative joint disease characterized by the destruction of joint cartilage. This perspective will discuss progress being made with the use of mesenchymal stem cells for the treatment of osteoarthritis oa with particular reference to current studies and the published literature to assess the potential of this emerging area of medicine. Stem cell therapy is seen as a potential new approach to the treatment of a range of chronic disease states.

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Knee osteoarthritis is a common condition that happens when the cartilage that cushions the knee joint starts to wear down.

Mesenchymal stem cells knee osteoarthritis.

Many patients with osteoarthritis of the knee fail non operative measures and elect to have knee arthroplasty to improve their quality of life. Mesenchymal stem cells mscs are found in low numbers in normal cartilage mainly in the superficial layer acting as repairing agents. Mesenchymal stem cells which come from your bone marrow can grow into. Knee osteoarthritis oa is a common skeletal impairment that can cause many limitations in normal life activities.

Nikbinmesenchymal stem cell therapy for knee osteoarthritis. Numerous systematic reviews investigating the effects of mesenchymal stem cells mscs in treating knee osteoarthritis oa have been published with controversial conclusion. Stem cells injection for knee osteoarthritis oa is still a relatively new treatment and has not yet gained popularity. Stem cell therapy has been studied for decades for its regenerative potency in various diseases.

Preliminary report of four patients preliminary report of four patients int j rheum dis 142 2011 pp. We investigated the safety and efficacy of intra articular injection of placental mesenchymal stem cells mscs in knee oa healing. So the effectiveness safety and potential of mesenchymal stem cells mscs for knee oa treatment is worthy to be explored. The purpose of the overview was 1 to perform an overview of systematic reviews investigating mscs for knee oa and 2 to synthesize evidence qualitatively to assess.

Allogeneic cells would be cheaperand logistically moreconvenient themostobvious disadvantage of using these cells is the possibility of host immune rejection. Mesenchymal stromal cells however are immune privileged7 or immune evasive8 and inhibit. Stem cells are considered to be one of the greatest potential treatments to cure degenerative diseases. If successful intra articular mesenchymal stem cell msc injections into the knee may offer another viable non operative treatment modality.

However cell expansion makes the procedure slow and expensive.

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